Cadre Research will be at the BIO12 convention this summer in Boston (June 18-21). Swing by our booth to learn how scientific computing can help your company.
Note: If you will be participating in the conference business partnering events and would like to set up a short one-on-one meeting just drop us a note.
Research SERVICE:
DUE DILIGENCE & EXPERT Advice
Cadre's team includes a select group of Computer Science and Computational Biology university faculty with a range of expertise. Given the interdisciplinary nature of your research, just about every company sooner or later finds itself in need of the expertise, independent viewpoint, and resources of an outside expert.
- Learn what's state-of-the-art - Evaluate new approaches - Work through a problem - Identify the right tool - Avoid common pitfalls
When faced with combining multiple pieces of information, not all data is equally informative. Appropriate mathematics can address this problem and allow a researcher to appropriately incorporate all available data. Unfortunately we all too often see simple statistics being misapplied. As this cartoon shows, averaging isn't always the answer.
We send this email as we gear up for this summer's BIO12 convention (see sidebar). In this newsletter we highlight new technology for Deimmunizing Protein and Peptide Therapeutics as well as several core service offerings. For those new to Cadre, our offerings fall into two categories, Computational Research Services (e.g., Virtual Ligand Screening) and Translational Technology Development (e.g., Protein and Peptide Deimmunization). In both cases we address reasonably-sized, hard-but-doable, really-useful-to-be-solved problems. Each of these criteria is important. We feel it's important that our research partners fully understand the intellectual challenges of each collaboration. We're not in the business of overselling methodology. If we initiate a project it means we have a solid understanding of how long it will take and that the approach will be successful. And of course, the solution should have significant impact through providing improved efficiency or novel capability. It's great to improve efficiency by 50%, but it's even better to open new market segments. Cadre consists of a core group of interdisciplinary PhDs with degrees in the Computational and Life sciences complemented by a select group of university faculty. We aim to be the best in the world at what we do.
Technology Partners Wanted: Let Cadre Deimmunize Your Therapeutics
Cadre is proud to partner with Chris Bailey-Kellogg and Karl Griswold at Dartmouth College to offer their novel computational and experimental platform for deimmunizing peptide and protein therapeutics. Our technology reduces the time and cost of identifying and removing T-cell epitopes; and will be of interest to any company working to mitigate potential anti-therapeutic immune responses. For example, those developing biologics, biosimilars, and biobetters. With this technology, therapeutics can more quickly get to market and are less likely to exhibit immunogenicity related failures. Bailey-Kellogg and Griswold's algorithm employs pairwise objective functions and a T-cell epitope predictor to identify sets of mutations making Pareto optimal decisions regarding protein function and immunogenicity. The model has been computationally and experimentally validated on several test systems (including the deimmunization of staphylokinase, erythropoietin, and beta-lactamase). Their most recent methods and results were presented at RECOMB 2012 and a PEDS paper is currently in press. (2 page research brief)
We are seeking biotech and pharmaceutical companies for whom this technology would be of interest. If immunogenicity is something you worry about, get in touch with us.
Contract Research Service: Virtual Ligand Screening
Cadre now offers a contract research service for virtual ligand screening. The service was initially designed for companies that did not have in-house computational screening capabilities but is open to anyone. Docking services save resources when used as a virtual prescreen prior to wetlab experimental work. It allows you to focus on a small set of promising ligands without having to experimentally screen your entire compound library. Our methods can also predict the binding modes for a set of validated hits or leads. If a high-resolution protein structure is available for your target our experts can help. Get in touch today.
Contract Research at Cadre
Even if you're on the right track, you'll get run over if you're not moving fast enough. Many companies contact Cadre to develop custom computational solutions that allow them to maintain competitive advantage. In the era of large data sets and optimized experimental protocols, Cadre can allow you to reduce experiment costs, to improve experiment time, and to get the most from your data. Contact us when you're beginning a new research project, when you need to source a computational solution for your research, or when you need to talk with really cool Computer Scientists that understand the Life Sciences. Yes, we know what you're thinking, Computer Scientists can be cool.
