Cadre Research Labs (CRL) is a Scientific Computing Contract Research Group specializing in algorithm development and technology transfer for the biotech and pharmaceutical industries. Companies in these sectors frequently have specific research computing needs that go beyond off-the-shelf software. As a group of Computer Science and Life Science PhDs, Cadre provides unparalleled interdisciplinary research expertise. We specialize in the application of techniques from Machine Learning, Algorithm Development, Data Mining, and Computational Biology.
Contract Research Services & Technology Transfer
for the Computational and Life Sciences
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People often think an approach is good enough
until they see the correct solution Learn how a custom computational research or discovery tool from Cadre can provide missing capabilities or enhance your current research competencies. Improve your research efficiency and reduce costs.
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Optibrium StarDrop Nova - A New Generation of Possibilities Cadre recently partnered with Optibrium to assist in the development of Nova, the latest module of their flagship StarDrop software product. Nova allows researchers to rigorously explore the chemistry around selected hits. Starting from a parent compound, Nova uses a library of over 200 chemical transforms, representing typical manipulations of medicinal chemistry, to generate and score a broad range of molecular derivatives. Derivatives are then visualized and scored using Optibrium's leading ADME and P450 models, probabilistic scoring, and glowing molecule visualization. Nova presents a powerful tool for any drug discovery group.
This work was presented at the annual American Chemical Society meeting. StarDrop Nova is available today. Visit Optibrium and mention that Cadre sent you!
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Protein Therapeutic Deimmunization - Click to Inquire The majority of therapeutic proteins elicit an anti-biotherapeutic immune response (aBIR) in human patients, driving the search for strategies to detect, assess, and ameliorate potentially deleterious immune responses. Cadre has partnered with Professor Chris Bailey-Kellogg at Dartmouth College to offer their suite of computational and experimental tools for producing immunotolerant variants of therapeutic proteins, in which immunogenicity is reduced while therapeutic activity is maintained. The approach promises not only to improve the state of the art in humanization of antibodies, but also to open new doors to humanization of enzymes. - A.S. Parker, W. Zheng, K.E. Griswold, and C. Bailey-Kellogg, BMC Bioinf., 2010, 11:180.
- A.S. Parker, K.E. Griswold, and C. Bailey-Kellogg, Proc. Comp. Syst. Bioinf, Aug 2010, 9:100. |
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Let's face it, most Computer Scientists and Biologists speak different languages, place importance on different goals, and work within very different mental models. Individual members of the Cadre team speak both computer science and biology. We have served as translators for years. By thoroughly understanding both sides of the table, we accurately and efficiently deliver exactly what you need. |
